Causes of Parkinson's Disease

Understanding the Causes of Parkinson’s Disease

Parkinson’s disease (PD) is a progressive neurological disorder caused by the degeneration of dopamine-producing neurons in the brain, particularly in the substantia nigra region. While the exact cause remains unclear, several factors contribute to its development. Genetic mutations, such as in the LRRK2 and SNCA genes, play a role in familial cases. Environmental factors, including exposure to pesticides, heavy metals, or toxins, may increase risk. Aging is the most significant risk factor, as the disease primarily affects individuals over 60. Additionally, oxidative stress and inflammation may damage brain cells, compounding the condition. Continued research aims to uncover more precise causes and solutions.